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250-511 Administration of Symantec(TM) Data Loss(R) Prevention 11

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250-511 exam Dumps Source : Administration of Symantec(TM) Data Loss(R) Prevention 11

Test Code : 250-511
Test cognomen : Administration of Symantec(TM) Data Loss(R) Prevention 11
Vendor cognomen : Symantec
: 176 existent Questions

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Symantec Administration of Symantec(TM) Data

Symantec Introduces New term of advanced possibility insurance policy | killexams.com existent Questions and Pass4sure dumps

MOUNTAIN VIEW, Calif.--(business WIRE)--Symantec Corp. (NASDAQ:SYMC), the global leader in cyber safety, today added Symantec advanced haphazard insurance policy (ATP), the first solution that can notice and remediate superior threats across manage facets, from a separate console with only a click, complete and not using a new endpoint agents to set up.

advanced threats, reminiscent of ransomware, far flung entry trojans, advanced persistent threats (APTs) and 0 day attacks, are on the upward thrust and protection authorities can now not depend on the disburse of particular person aspect products at each and every manage element to cease them. The procedure of uncovering risk data across endpoint, community and electronic mail gateways is manual and time-drinking, which offers attackers an side. Symantec ATP correlates suspicious exercise throughout complete manipulate aspects and prioritizes the activities that pose probably the most risk to an organization. once a vital risk is recognized, it will possibly now exist rapidly contained and new instances may too exist blocked.

Symantec ATP makes it feasible for valued clientele to:

  • discover a replete ambit of threats from APTs to zero day assaults throughout endpoint, community and electronic mail, with pass-handle factor detection and environmental search
  • Prioritize what concerns most by pass of correlating the possibility intelligence from throughout local control facets with complete that Symantec sees globally through its great telemetry
  • Remediate the threats speedy through containment of endpoints and blocking off new cases throughout manage aspects, with one click, from a separate console
  • Leverage latest investments in Symantec Endpoint safety and e mail safety.cloud, with out deploying any new endpoint brokers
  • “security gurus are constantly on their toes trying to display screen and stop the subsequent cyber-attack,” mentioned Michael A. Brown, president and CEO, Symantec. “We’re relocating the trade forward with Symantec advanced danger protection with the aid of giving clients an entire photo of their gross traffic from a separate console. Now they could lucid out the clamor and quickly find and remediate an assault.”

    cutting back the clamor for customers with Symantec ATP occurs in a brace of methods. First, Symantec’s ample world possibility intelligence combined with local customer records means companies own a more redress view of which threats pose the greatest risk interior their infrastructure. moreover, Symantec ATP comprises Symantec CynicTM, a brand new cloud-based sandboxing and payload detonation carrier to find and prioritize nowadays’s most superior threats. It additionally includes SynapseTM, a pass-control aspect correlation faculty that collects suspicious activity across endpoints, networks and e-mail to prioritize people who are of premiere possibility to the firm.

    “Our new Synapse and Cynic technologies labor together to supply up to 30 percent superior detection than latest products out there1,” said Balaji Yelamanchili, executive vice president and accepted manager of enterprise security company, Symantec. “earlier than, a security professional would exigency to manually determine to peer if a suspicious file became appropriately blocked. With their new applied sciences constructed into Symantec ATP, they enact the legwork for shoppers, cutting down on their search and remediation time.”

    “The regular traffic uses 75 distinctive protection products,” Yelamanchili added. “That overload creates possibility for attackers because it slows down detection. Symantec ATP makes it feasible for security professionals to click on as soon as and remediate complete over across complete three control features.”

    Symantec ATP enhances present installations of SymantecTM Endpoint coverage and e mail protection.cloud devoid of requiring any new endpoint brokers. This enables consumers to installation a brand new installing of Symantec ATP in under an hour and hunt attacks in minutes. The product can too export its wealthy intelligence into third birthday celebration security incident undergo managers (SIEMs). As Symantec ATP evolves, the enterprise plans to open it up to third party technology partners, together with firewall and different security product vendors, allowing consumers to enlarge the cost of their current investments.

    aiding costs

  • “Securing a ample pan-European stock exchange is tall stakes and their IPO in 2014 introduced an colossal diploma of complexity to securing their facts. as the world has viewed, one technical glitch can rock the markets and cause fiscal, criminal and reputational harm. Euronext became to market-chief Symantec to at ease its infrastructure and signed on to leer at various an early version of Symantec’s superior probability insurance plan. Already it’s featuring improved visibility into what’s happening on Euronext’s endpoints; and doing it in a less complicated, quicker more efficient way. because of this, Euronext has prioritised and reduced the variety of talents safety incidents,” renowned Marc green, Head of haphazard and Vulnerability management, Euronext.
  • “in reality, going forward, greater prevention, detection, response and prediction capabilities are complete crucial to contend with every benevolent of attacks, ‘advanced’ or now not. in addition, these should quiet no longer exist viewed as siloed capabilities; rather, they may quiet labor intelligently together as an built-in, adaptive device to constitute an entire insurance plot system for advanced threats.” (supply: Gartner, Designing an Adaptive security architecture for insurance policy From superior attacks 12 February 2014, Gartner Foundational 19 November 2014)
  • “As corporations' security estates become greater complicated, in response to a dynamic danger panorama, CISOs claim a platform that integrates and manages their safety operations. in a similar way, to address competencies shortages, they exigency a mechanism that automates as an abominable lot of their safety operations as feasible, and in specific detects and remediates threats birthright away,” mentioned Duncan Brown, analysis Director, European protection practice, IDC.
  • “Our strategic relationship with Symantec has bought an extra raise with the addition of the Symantec superior probability protection. at the present time of cyber threats, they firmly agree with that ATP will tremendously raise valued clientele’ defenses by means of embedding sophisticated possibility detection and remediation capabilities into their current security portfolio. by using leveraging Wipro’s commercial enterprise protection solutions’ potential and Symantec’s efficient expertise prowess, they are expecting to considerably enhance their shoppers’ self-possession in their Cyber insurance plot and risk management approach,” referred to Sheetal Mehta, VP & international Head – commercial enterprise safety options, Wipro.
  • “In nowadays’s dynamic world, corporations, greater than ever, are challenged by pass of safety requirements because the facts resides in public, inner most and virtual environments. The verity of the BYOD phenomenon internal corporations own made facts possibility management the entire extra vital,” referred to Kalyan Kumar, SVP & Chief Technologist, HCL technologies. “In this benevolent of status of affairs, Symantec advanced threat protection is a state-of–the-paintings respond that not handiest acts as an early warning device however allows consumers to Take replete edge of Symantec’s vast amounts of threat intelligence to aid prioritize the incidents that aren’t caught by pass of different factor products across the enterprise IT atmosphere. It’s precisely what their purchasers are seeking – a simple technique to manage and forestall the next mega breach.”
  • Pricing and Availability

    Symantec superior haphazard coverage might exist obtainable by using conclusion of calendar 12 months 2015.starting MSRP is $40 per person yearly to at ease one manage pointStarting MSRP is $60 per person yearly to cozy two manipulate pointsStarting MSRP is $70 per person annually to relaxed three manage elements

    About Symantec

    Symantec agency (NASDAQ:SYMC) is the global leader in cybersecurity. operating one of the most world’s largest cyber intelligence networks, they notice more threats, and give protection to greater shoppers from the subsequent era of assaults. We assist organizations, governments and individuals relaxed their most crucial records at any region it lives.

    forward-looking STATEMENTS: Any ahead-looking indication of plans for items is prefatory and complete future liberate dates are tentative and are discipline to change. Any future free up of the product or planned modifications to product ability, functionality, or function are discipline to ongoing contrast through Symantec, and might or might too not exist applied and should not exist considered firm commitments by Symantec and may not exist relied upon in making procuring selections.

    1 supply: Miercom, Symantec advanced haphazard insurance policy: network, April 2015. http://miercom.com/pdf/experiences/20150218.pdf


    CrowdStrike vs Symantec: properly EDR options in comparison | killexams.com existent Questions and Pass4sure dumps

    Most synchronous products Articles

    Endpoint security products from CrowdStrike and Symantec both made eSecurity Planet's record of top conclusion point detection and response (EDR) solutions – and while each and every product has an abominable lot to tender traffic shoppers, there are key variations between them. What follows an analysis of every solution's key aspects, in addition to some strengths and weaknesses.

    The basis line

    each solutions are rated highly through clients in addition to traffic analysts. CrowdStrike's cloud structure makes deployment strangely short and easy, notwithstanding the incontrovertible fact that or not it's a long pass less beneficial offline makes it unsuitable for air-gapped networks. Symantec offers each an on-premises solution and a cloud-primarily based one, featuring a wider ambit of alternatives for shoppers – but it's frequently considered as being greater complicated to manage than its opponents.

    CrowdStrike EDR Highlights

    Overview: CrowdStrike Falcon insight leverages signatureless AI and indicator-of-assault (IOA) based mostly probability prevention to tender protection to users from complete kinds of cyberattacks. Falcon offers contextualized probability intelligence with particulars on the hazard, and a five-second search tool allows for teams to determine and investigate current and historic possibility exercise by means of going lower back one 2nd, someday or one year of pastime. The solution’s cloud-based mostly architecture is designed to give rapid response without placing any stress on purchasers' endpoints.

    recent traits: improvements over the past twelve months encompass:

  • a tool manage characteristic for visibility and administration of USB instruments
  • A Vulnerability assessment characteristic, opting for vulnerabilities and missing updates on endpoints through immediately monitoring and examining patches on each and every system
  • Mapping of detection to a framework based on MITRE ATT&CK to precipitate up figuring out, triage and response
  • true-time response movements
  • Docker support, allowing the setting up of the Falcon agent on hosts operating the Docker container platform so the host can exist secured while consumers disburse Docker
  • elevated integration of the Falcon OverWatch managed detection and response carrier
  • https://o1.qnsr.com/log/p.gif?;n=203;c=204660769;s=9477;x=7936;f=201812281319310;u=j;z=TIMESTAMP;a=20394213;e=i

    Analysts' take: Gartner says the combination of Falcon OverWatch with Falcon perception EDR is certainly compelling for businesses with wee or no SOC teams. The Falcon insight EDR agent offers parity throughout home windows, Mac OS and Linux systems, and valued clientele document essential and straightforward deployments, in fraction as a result of the answer's cloud structure. nevertheless, the research firm says Falcon's EDR functionality requires knowledgeable technical personnel to invent disburse of, and its offline insurance plot is vastly superior when related to the cloud-based Falcon platform, making it unsuitable for air-gapped (secure, remoted) networks.

    Symantec EDR Highlights

    Overview: Symantec EDR uses behavioral evaluation at the endpoint and AI-based mostly analytics in the cloud to determine superior assaults. The respond provides a comprehensive set of detection, investigation and remediation capabilities for complete tiers of investigators, together with automatic investigation playbooks and user conduct analytics. Incident responders can immediately search, determine and comprise impacted endpoints whereas investigating threats the usage of a determination of on-premises and cloud-primarily based sandboxing.

    recent tendencies: improvements over the ultimate 12 months include:

  • assist for targeted assault Analytics (TAA), leveraging AI algorithms to become vigilant of suspicious undertaking and rising threats in Symantec Endpoint insurance plot information accumulated and correlated in a colossal records lake
  • guide for MITRE ATT&CK tactics and ideas and MITRE Cyber Analytics, enabling investigators to leer and filter hobbies and incidents by MITRE ATT&CK tactics with a purpose to map movements to the ATT&CK matrix
  • brought more than a dozen detections from the MITRE Cyber Analytics Repository (motor vehicle) as computerized investigation playbooks
  • Analysts' take: Gartner says Symantec is the primary seller to tender malware coverage, EDR, device hardening and deception capabilities in a separate agent, and its great deployment throughout a really tremendous population of both client and company endpoints offers it a very huge view into the haphazard landscape throughout many verticals. still, the research company says Symantec is perceived as extra intricate and useful resource-intensive to manipulate than its competitors, and its managed safety capabilities are extra expensive than those from more recent providers.

    EDR Product rankings

    listed here are eSecurity Planet's scores of every solution's key facets.

    performance: shoppers of each vendors record solid performance, with minimal own an sequel on on endpoints. essentially the most fresh Forrester Wave file on EDR options gave CrowdStrike the optimum ranking of complete EDR companies proven – 4.fifty six out of five – and gave Symantec a score of two.72 out of five. The rating is based on a variety of criteria, including configurability, agent effectiveness, forensic capabilities, deployment alternatives and response movements.

    Detection and response: In fresh checking out, Forrester rated CrowdStrike's detection capabilities at four.eight out of 5, and its response capabilities at four.6 out of 5. Symantec's detection capabilities were rated at 2.0 out of 5, and its response capabilities at four.2 out of 5. Symantec shoppers report stronger possibility detection and containment with the addition of computer getting to know and other superior anti-malware facets, Gartner noted.

    cost: while CrowdStrike is extra expensive than many other options, cloud statistics storage and managed detection and response are protected. Symantec presents managed features, however those features are greater tall priced than those from other providers.

    Implementation and management: CrowdStrike's cloud architecture makes deployment certainly effortless, whatever clients time and again cite in studies. Symantec presents each cloud-primarily based and on-premises alternate options, making it more desirable suited for hybrid environments. both options require expert technical personnel to manage, although managed detection and response services can exist found.

    assist: Gartner says Symantec purchasers file incongruous assist experiences, even when giant organizations are offered with committed wait on personnel. nevertheless, some reviewers spoke of the identical of CrowdStrike's tech aid.

    Cloud features: both organizations present cloud-based mostly options, besides the fact that children CrowdStrike's offering is purely cloud-based, giving Symantec the fraction in hybrid environments.

    CrowdStrike vs Symantec 

    consumer studies

    Gartner Peer Insights clients give CrowdStrike Falcon an medium rating of four.6 out of 5, with Symantec EDR following at a yardstick of four.0 stars out of 5. IT imperative Station clients supply CrowdStrike 4.0 stars out of 5, and Symantec four.1 out of 5.

    CrowdStrike reviewers repeatedly stated the product’s ease of deployment, calling it "short and easy to install" and reporting that "the sensor is truly lightweight and has no longer been considerable when operating on even aid-limited computer systems." different reviewers wrote that "the hobbies administration of this respond is manageable," and that CrowdStrike has "a different proposition with their cloud-primarily based manner as neatly because the research group."

    Symantec reviewers said that "implementation changed into effortless." They referred to "short whitelisting and blacklisting and informative reporting" as key advantages, including that the respond "has provided visibility insights that they were no longer receiving from other items." yet another reviewer pointed out the product "matches very neatly with their existing strategies and strategies," calling it "a superb product to give protection to your environment."

    study more experiences written via users of CrowdStrike and Symantec.

    Deployment

    The CrowdStrike Falcon platform is absolutely cloud-based mostly, allowing it to exist deployed within hours, and supports windows, Mac and Linux programs.

    Symantec EDR presents cloud, on-premises and hybrid deployment models, and supports windows, Mac and Linux methods.

    Pricing

    CrowdStrike Falcon insight is purchasable for an annual subscription payment per endpoint, with a free crucible purchasable. AWS gives some pricing information.

    Symantec EDR is priced per consumer per 12 months, with quantity discounting. Trials can exist found. CDW presents some pricing information.


    Symantec warns of China-based espionage drive targeting satellites | killexams.com existent Questions and Pass4sure dumps

    A China-based mostly cyber group is carrying out an extensive hacking drive by pass of focused on satellite, telecom and protection organizations in the united states and Southeast Asia, a U.S. cybersecurity company warned this week.

    The purpose of the hacking group, called "Thrip," is probably going countrywide cyber espionage, safety researchers at Symantec Corp. mentioned on Tuesday.

    "Thrip’s beset on telecoms and satellite tv for pc operators exposes the probability that the attackers could intercept or even alter communications traffic from enterprises and consumers," Symantec spoke of in a press release, including that the most stressful discovery is an try to manipulate satellites by means of infecting linked computer systems with malware.

    commercial

    "The assault community gave the impression to exist principally drawn to the operational aspect of the company, hunting for and infecting computer systems running application that screens and controls satellites. this suggests to us that Thrip’s factors Go beyond spying and can additionally encompass disruption," Symantec wrote in a separate blog publish.

    Satellites play a famous function in telecommunications, receiving and transmitting phone and information superhighway alerts as well as mapping and geolocation information.

    Symantec observed in Tuesday's observation that it has tracked Thrip in view that 2013 and currently followed that the cyber group looks to own "found out new tools and concepts used via the community in this most fresh set of attacks."

    The possibility of the more suitable hacking toolbox is extra compounded by pass of Thrip's means to reside smartly hidden.

    "They function very quietly, blending in to networks, and are most efficient establish the disburse of simulated intelligence that may determine and flag their actions," Symantec Chief government Greg Clark renowned in a statement.

    The traffic says it establish out the new attacks through its simulated intelligence-based targeted assault Analytics, which helped the researchers spot the malicious habits that become hiding in reputable IT administration equipment.


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    Administration of Symantec(TM) Data Loss(R) Prevention 11

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    BioCryst Reports Fourth Quarter and replete Year 2018 monetary Results | killexams.com existent questions and Pass4sure dumps

    —APeX-2 24-week safety and efficacy data of once-daily oral BCX7353 for prophylaxis of hereditary angioedema (HAE) attacks on-track for Q2 2019—

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    —Recent $100 million debt financing increases monetary flexibility—

    RESEARCH TRIANGLE PARK, N.C., March 04, 2019 (GLOBE NEWSWIRE) -- BioCryst Pharmaceuticals, Inc. (BCRX) today announced monetary results for the fourth quarter and replete year ended December 31, 2018, and provided a corporate update.

    “In a year with many transformative milestones for BioCryst, it has been exciting to notice so much progress already in the first two months of the year. The stout aspect 2 clinical data from their now-completed ZENITH-1 crucible propels their BCX7353 acute program for HAE into aspect 3 development. With the very conducive preclinical profile of BCX9930, another novel BioCryst-invented oral drug for rare diseases, they are advancing that program into the clinic in the second quarter for the treatment of complement-mediated diseases. They too added further rare disease expertise to their board and increased their monetary flexibility with a $100 million debt agreement,” said Jon Stonehouse, president and chief executive officer of BioCryst.

    “We remain on-track for the readout of their APeX-2 crucible next quarter, and an NDA filing of BCX7353 for HAE prophylaxis by the discontinue of the year. They are thoughtfully building their commercial leadership and infrastructure to execute a successful launch that meets the pressing claim for a once-daily oral therapy that will allow HAE patients to live a more timehonored life,” Stonehouse added.

    Recent Milestones

  • The company has dosed the first patients in its APeX-J crucible in Japan, designed to champion potential Japanese approval of BCX7353 for the prevention of HAE attacks. 
  • On March 4, 2019, the company announced that it is advancing BCX9930, an oral Factor D inhibitor, into aspect 1 clinical evolution in the second quarter of 2019 for the treatment of complement-mediated diseases.
  • On February 23, 2019, the company announced data from the completed ZENITH-1 crucible (including the 250 mg and 500 mg dose cohorts) of BCX7353 for the acute treatment of HAE attacks at the annual meeting of the American Academy of Allergy, Asthma & Immunology. The company plans to commence a aspect 3 trial, ZENITH-2, in the summer of 2019. 
  • On February 6, 2019, the company announced it had entered into a $100 million secured credit facility with MidCap monetary faith pursuant to the terms and conditions of an amended and restated credit and security agreement. 
  • On January 4, 2019, the company announced it had appointed Steve Aselage to its board of directors. 
  • On January 2, 2019, the company announced the dosing of the first matter in a randomized, placebo-controlled aspect 1 clinical crucible to evaluate intravenous galidesivir, its investigational broad-spectrum antiviral drug, in healthy volunteers.
  • Fourth Quarter 2018 Corporate Developments

  • On November 20, 2018, BioCryst announced that it had appointed Theresa Heggie to its board of directors. 
  • On November 16, 2018, BioCryst presented data that showed an oral formulation of BCX7353 was rapidly absorbed and exhibited a long half-life, two famous characteristics of desired new acute treatments for HAE attacks, at the annual scientific meeting of the American College of Allergy, Asthma & Immunology.
  • Upcoming Key Milestones

    HAE Program – BCX7353

  • Report 24-week safety and efficacy results from the APeX-2 clinical crucible (Q2 2019) 
  • Begin a aspect 3 clinical crucible of oral BCX7353 for the acute treatment of HAE (Summer 2019) 
  • File a new drug application (NDA) for oral BCX7353 for the prevention of HAE attacks with the U.S. Food and Drug Administration (FDA) (Q4 2019)
  • Complement Factor D Inhibitor Program – BCX9930

  • Begin a aspect 1 crucible of BCX9930, an oral Factor D inhibitor for treatment of complement-mediated diseases, in healthy subjects (Q2 2019) 
  • Report aspect 1 results (Q4 2019)
  • ALK-2 Inhibitor Program – BCX9250

  • Begin a aspect 1 clinical crucible of BCX9250, an oral ALK-2 kinase inhibitor for treatment of fibrodysplasia ossificans progressiva, in healthy subjects (2H 2019)
  • Fourth Quarter 2018 monetary Results

    For the three months ended December 31, 2018, total revenues were $2.7 million, compared to $3.9 million in the fourth quarter of 2017. The dwindle was primarily due to a reduction of royalty revenue associated with differences in the onset and severity of the influenza seasons between the two periods. This dwindle was partially offset by increased revenue from government contracts for galidesivir development, which was higher in the fourth quarter of 2018.

    Research and evolution (R&D) expenses for the fourth quarter of 2018 increased to $23.4 million from $16.9 million in the fourth quarter of 2017, primarily due to increased spending on the company’s HAE and preclinical programs.

    General and administrative (G&A) expenses for the fourth quarter of 2018 decreased slightly to $4.5 million, compared to $4.7 million in the fourth quarter of 2017. The dwindle was primarily due to the want of merger-related costs in the fourth quarter of 2018 associated with the company’s terminated merger with Idera Pharmaceuticals, Inc. (Idera). The dwindle in G&A expense due to the want of merger expenses was largely offset by higher commercial and medical affairs expenses in the fourth quarter of 2018.

    Interest expense was $2.4 million in the fourth quarter of 2018, compared to $2.2 million in the fourth quarter of 2017 and was associated with enhancing their secured credit facility in July 2018.

    Net loss for the fourth quarter of 2018 was $27.4 million, or $0.25 per share, compared to a net loss of $19.5 million, or $0.20 per share, for the fourth quarter of 2017. 

    Cash, cash equivalents and investments totaled $128.4 million at December 31, 2018, and reflect a dwindle from $159.0 million at December 31, 2017. Cash and investments reflect the proceeds from a July 2018 enhancement to their secured credit facility and an August 2018 public equity offering, offset by timehonored operating expenses and merger-related costs incurred in the 12-month period. Operating cash disburse for the fourth quarter of 2018 was $22.6 million, and for the replete year of 2018 was $93.4 million.

    On February 6, 2019, the company announced it had entered into a $100 million secured credit facility with MidCap monetary faith which further enhanced the company’s cash position with $20 million of immediate additional non-dilutive capital and provided additional monetary flexibility by providing the faculty to draw another $50 million of milestone-based non-dilutive capital.

    Story continues

    Full Year 2018 monetary Results

    For the replete year ended December 31, 2018, total revenues were $20.7 million, compared to $25.2 million in the replete year ended December 31, 2017. The dwindle in revenue was primarily associated with infrequent revenue events that occurred in 2017 that did not recur in 2018, as well as a $2.1 million dwindle in revenue associated with evolution activities under U.S. government contracts in 2018. The non-recurring 2017 events were the recognition of $4.1 million of royalty revenue from Japanese government stockpiling of RAPIACTA® and the recognition of $1.5 million of peramivir product sales from the company’s commercial partner, Green Cross Corporation. These decreases were partially offset by a $5.0 million milestone associated with the European Medicines Agency’s (EMA) approval of peramivir (ALPIVABTM) recognized in the second quarter of 2018.

    R&D expenses in 2018 increased to $84.9 million from $67.0 million in 2017, primarily due to increased spending on their HAE and preclinical programs. These increases were partially offset by a dwindle in the company’s peramivir and galidesivir evolution spending in 2018.

    G&A expenses in 2018 increased to $29.5 million, compared to $13.9 million in 2017. The enlarge was primarily due to approximately $11 million of merger-related costs associated with the company’s terminated merger with Idera and a $4.9 million reserve for collectability of the EMA approval milestone of peramivir.

    Interest expense was $9.2 million in 2018, compared to $8.6 million in 2017.

    Net loss for 2018 was $101.3 million, or $0.98 per share, compared to a net loss of $65.8 million, or $0.78 per share, for 2017. 

    Financial Outlook for 2019 

    BioCryst expects net operating cash disburse to exist in the ambit of $105 to $130 million, and its 2019 operating expenses to exist in the ambit of $120 to $145 million. The company’s operating expense ambit excludes equity-based compensation expense due to the vicissitude in reliably projecting this expense, as it is impacted by the volatility and expense of the company’s stock, as well as by the vesting of the company’s outstanding performance-based stock options.

    Conference convoke and Webcast

    BioCryst management will host a conference convoke and webcast at 8:30 a.m. ET today to argue the monetary results and provide a corporate update. The live convoke may exist accessed by dialing 877-303-8027 for domestic callers and 760-536-5165 for international callers and using conference ID # 1271286. A live webcast of the convoke and any slides will exist available online at the investors section of the company website at www.biocryst.com. A telephone replay of the convoke will exist available by dialing 855-859-2056 for domestic callers or 404-537-3406 for international callers and entering the conference ID# 1271286.

    About BioCryst Pharmaceuticals

    BioCryst Pharmaceuticals discovers novel, oral small-molecule medicines that treat rare diseases in which significant unmet medical needs exist and an enzyme plays a key role in the biological pathway of the disease. BioCryst has several ongoing evolution programs including BCX7353, an oral treatment for hereditary angioedema, BCX9930, an oral Factor D inhibitor for the treatment of complement-mediated diseases, galidesivir, a potential treatment for Marburg virus disease and Yellow Fever, and a preclinical program to develop oral ALK-2 inhibitors for the treatment of fibrodysplasia ossificans progressiva. RAPIVAB® (peramivir injection), a viral neuraminidase inhibitor for the treatment of influenza, is BioCryst's first approved product and has received regulatory approval in the U.S., Canada, Australia, Japan, Taiwan, Korea and the European Union. Post-marketing commitments for RAPIVAB are ongoing. For more information, please visit the Company's website at www.BioCryst.com.

    Forward-Looking Statements

    This press release contains forward-looking statements, including statements regarding future results, performance or achievements. These statements involve known and unknown risks, uncertainties and other factors which may cause BioCryst’s actual results, performance or achievements to exist materially different from any future results, performances or achievements expressed or implied by the forward-looking statements. These statements reflect their current views with respect to future events and are based on assumptions and are matter to risks and uncertainties. Given these uncertainties, you should not region undue reliance on these forward-looking statements. Some of the factors that could strike the forward-looking statements contained herein include: that developing any HAE product candidate may Take longer or may exist more expensive than planned; that ongoing and future preclinical and clinical evolution of BCX9930, BCX9250 and their HAE second generation drug candidates (including APeX-2, APeX-S and APeX-J) may not own positive results; that BioCryst may not exist able to enroll the required number of subjects in planned clinical trials of product candidates; that the company may not promote human clinical trials with product candidates as expected; that the FDA, EMA or other applicable regulatory agency may require additional studies beyond the studies planned for product candidates, or may not provide regulatory clearances which may result in retard of planned clinical trials, or may impose a clinical hold with respect to such product candidate, or withhold market approval for product candidates; that actual monetary results may not exist consistent with expectations, including that 2019 operating expenses and cash usage may not exist within management's expected ranges. please refer to the documents BioCryst files periodically with the Securities and Exchange Commission, specifically BioCryst’s most recent Annual Report on profile 10-K, Quarterly Reports on profile 10-Q, and Current Reports on profile 8-K, complete of which identify famous factors that could cause the actual results to disagree materially from those contained in BioCryst’s projections and forward-looking statements.

    BCRXW

    Contact:John Bluth+1 919 859 7910jbluth@biocryst.com

    BIOCRYST PHARMACEUTICALS, INC. CONSOLIDATED monetary SUMMARY (in thousands, except per share)                                   Statements of Operations (Unaudited)                                                                   Three Months Ended       Twelve Months Ended       December 31,       December 31,       2018       2017       2018       2017   Revenues:                               Product sales $ -     $ -     $ -     $ 1,501   Royalty revenue   1,775       3,291       6,101       10,543   Collaborative and other research and development   954       599       14,552       13,142   Total revenues   2,729       3,890       20,653       25,186                                   Expenses:           Cost of product sales   -       -       -       1,142   Research and development   23,431       16,924       84,888       66,962   General and administrative   4,490       4,698       29,514       13,933   Royalty   70       129       471       560   Total operating expenses   27,991       21,751       114,873       82,597                                   Loss from operations   (25,262 )     (17,861 )     (94,220 )     (57,411 )                                 Interest and other income   686       478       2,252       1,015   Interest expense   (2,414 )     (2,231 )     (9,176 )     (8,565 ) (Loss) gain on curious currency derivative   (442 )     71       (108 )     (821 )                                 Net loss $ (27,432 )   $ (19,543 )   $ (101,252 )   $ (65,782 )                                 Basic and diluted net loss per common share $ (0.25 )   $ (0.20 )   $ (0.98 )   $ (0.78 )                                 Weighted medium shares outstanding   109,802       98,402       103,185       84,451                                                                                                                                   Balance Sheet Data (in thousands)                                 December 31, 2018     December 31, 2017     (Unaudited)     (Note 1)   Cash, cash equivalents and investments   $  126,843           $  155,692       Restricted cash   1,544           3,286       Receivables from collaborations   4,293           6,117       Total assets   146,841           178,259       Non-recourse notes payable   29,121           28,682       Senior credit facility   29,952           23,214       Accumulated deficit   (731,969 )         (631,843 )     Stockholders’ equity   49,235           83,767       Shares of common stock outstanding   110,063           98,411                                       Note 1:  Derived from audited monetary statements.                              

    Antitumor activity of CD56-chimeric antigen receptor T cells in neuroblastoma and SCLC models | killexams.com existent questions and Pass4sure dumps

  • 1.

    Larkin J, Chiarion-Sileni V, Gonzalez R, Grob JJ, Cowey CL, Lao CD, et al. Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. N Engl J Med. 2015;373:23–34.

  • 2.

    Garon EB, Rizvi NA, Hui R, Leighl N, Balmanoukian AS, Eder JP, et al. Pembrolizumab for the treatment of non-small-cell lung cancer. N Engl J Med. 2015;372:2018–28.

  • 3.

    Page DB, Postow MA, Callahan MK, Allison JP, Wolchok JD. Immune modulation in cancer with antibodies. Annu Rev Med. 2014;65:185–202.

  • 4.

    Ott PA, Elez E, Hiret S, Kim DW, Morosky A, Saraf S, et al. Pembrolizumab in patients with extensive-stage wee cell lung cancer: updated survival results from KEYNOTE-028 2016. J Clin Oncol. 2017;35:3823–9.

  • 5.

    Taylor M, Antonia S, Bendell J, Calvo E, Jäger D, de Braud F, et al. aspect I/II study of nivolumab with or without ipilimumab for treatment of recurrent wee cell lung cancer (SCLC): CA209-032. J Immunotherapy Cancer. 2015;3:P376.

  • 6.

    Antonia SJ, Lopez-Martin JA, Bendell J, Ott PA, Taylor M, Eder JP, et al. Nivolumab lonesome and nivolumab plus ipilimumab in recurrent small-cell lung cancer (CheckMate 032): a multicentre, open-label, aspect 1/2 trial. Lancet Oncol. 2016;17:883–95.

  • 7.

    Yu AL, Gilman AL, Ozkaynak MF, London WB, Kreissman SG, Chen HX, et al. Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma. N Engl J Med. 2010;363:1324–34.

  • 8.

    Chen HL, Gabrilovich D, Tampe R, Girgis KR, Nadaf S, Carbone DP. A functionally defective allele of TAP1 results in loss of MHC class I antigen presentation in a human lung cancer. Nat Genet. 1996;13:210–3.

  • 9.

    Zaretsky JM, Garcia-Diaz A, Shin DS, Escuin-Ordinas H, Hugo W, Hu-Lieskovan S, et al. Mutations associated with acquired resistance to PD-1 blockade in melanoma. N Engl J Med. 2016;375:819–29.

  • 10.

    Yoshihama S, Roszik J, Downs I, Meissner TB, Vijayan S, Chapuy B, et al. NLRC5/MHC class I transactivator is a target for immune evasion in cancer. Proc Natl Acad Sci USA. 2016;113:5999–6004.

  • 11.

    Dalmau J, Graus F, Cheung NK, Rosenblum MK, Ho A, Canete A, et al. Major histocompatibility proteins, anti-Hu antibodies, and paraneoplastic encephalomyelitis in neuroblastoma and wee cell lung cancer. Cancer. 1995;75:99–109.

  • 12.

    Jena B, Dotti G, Cooper LJ. Redirecting T-cell specificity by introducing a tumor-specific chimeric antigen receptor. Blood. 2010;116:1035–44.

  • 13.

    Shah MH, Lorigan P, O’Brien ME, Fossella FV, Moore KN, Bhatia S, et al. aspect I study of IMGN901, a CD56-targeting antibody-drug conjugate, in patients with CD56-positive solid tumors. Invest New Drugs. 2016;34:290–9.

  • 14.

    Feng Y, Wang Y, Zhu Z, Li W, Sussman RT, Randall M, et al. Differential killing of CD56-expressing cells by drug-conjugated human antibodies targeting membrane-distal and membrane-proximal non-overlapping epitopes. MAbs. 2016;8:799–810.

  • 15.

    Graus F, Dalmou J, Rene R, Tora M, Malats N, Verschuuren JJ, et al. Anti-Hu antibodies in patients with small-cell lung cancer: association with complete response to therapy and improved survival. J Clin Oncol. 1997;15:2866–72.

  • 16.

    Kazarian M, Laird-Offringa IA. Small-cell lung cancer-associated autoantibodies: potential applications to cancer diagnosis, early detection, and therapy. Mol Cancer. 2011;10:33.

  • 17.

    Winter SF, Sekido Y, Minna JD, McIntire D, Johnson BE, Gazdar AF, et al. Antibodies against autologous tumor cell proteins in patients with small-cell lung cancer: association with improved survival. J Natl Cancer Inst. 1993;85:2012–8.

  • 18.

    Schreiber RD, feeble LJ, Smyth MJ. Cancer immunoediting: integrating immunity’s roles in cancer suppression and promotion. Science. 2011;331:1565–70.

  • 19.

    Noble A, Giorgini A, Leggat JA. Cytokine-induced IL-10-secreting CD8 T cells limn a phenotypically discrete suppressor T-cell lineage. Blood. 2006;107:4475–83.

  • 20.

    Kelly-Rogers J, Madrigal-Estebas L, O’Connor T, Doherty DG. Activation-induced expression of CD56 by T cells is associated with a reprogramming of cytolytic activity and cytokine secretion profile in vitro. Hum Immunol 2006;67:863–73.

  • 21.

    Ohkawa T, Seki S, Dobashi H, Koike Y, Habu Y, Ami K, et al. Systematic characterization of human CD8 + T cells with natural killer cell markers in comparison with natural killer cells and timehonored CD8 + T cells. Immunology. 2001;103:281–90.

  • 22.

    Pittet MJ, Speiser DE, Valmori D, Cerottini JC, Romero P. Cutting edge: cytolytic effector function in human circulating CD8 + T cells closely correlates with CD56 surface expression. J Immunol. 2000;164:1148–52.

  • 23.

    Socinski MA, Kaye FJ, Spigel DR, Kudrik FJ, Ponce S, Ellis PM, et al. aspect 1/2 study of the CD56-targeting antibody-drug conjugate lorvotuzumab mertansine (IMGN901) in combination with carboplatin/etoposide in small-cell lung cancer patients with extensive-stage disease. Clin Lung Cancer. 2017;18:68–76. e62

  • 24.

    Whiteman KR, Johnson HA, Mayo MF, Audette CA, Carrigan CN, LaBelle A, et al. Lorvotuzumab mertansine, a CD56-targeting antibody-drug conjugate with potent antitumor activity against wee cell lung cancer in human xenograft models. MAbs. 2014;6:556–66.

  • 25.

    Doyle A, Martin WJ, Funa K, Gazdar A, Carney D, Martin SE, et al. Markedly decreased expression of class I histocompatibility antigens, protein, and mRNA in human small-cell lung cancer. J Exp Med. 1985;161:1135–51.

  • 26.

    Fisk B, Ioannides CG, Aggarwal S, Wharton JT, O’Brian CA, Restifo N, et al. Enhanced expression of HLA-A,B,C and inducibility of TAP-1, TAP-2, and HLA-A,B,C by interferon-gamma in a multidrug-resistant wee cell lung cancer line. Lymphokine Cytokine Res. 1994;13:125–31.

  • 27.

    Yazawa T, Ito T, Kamma H, Suzuki T, Okudela K, Hayashi H, et al. Complicated mechanisms of class II transactivator transcription deficiency in wee cell lung cancer and neuroblastoma. Am J Pathol. 2002;161:291–300.

  • 28.

    Ryan SO, Turner MS, Gariepy J, Finn OJ. Tumor antigen epitopes interpreted by the immune system as self or abnormal-self differentially strike cancer vaccine responses. Cancer Res. 2010;70:5788–96.

  • 29.

    Bruns M, Wanger J, Schumacher U, Deppert W. T-cell epitope energy in WAP-T mouse mammary carcinomas is an famous determinant in PD1/PD-L1 immune checkpoint blockade therapy. Oncotarget. 2016;7:64543–59.

  • 30.

    Michielsen AJ, Noonan S, Martin P, Tosetto M, Marry J, Biniecka M, et al. Inhibition of dendritic cell maturation by the tumor microenvironment correlates with the survival of colorectal cancer patients following bevacizumab treatment. Mol Cancer Ther. 2012;11:1829–37.

  • 31.

    Sakemura R, Terakura S, Watanabe K, Julamanee J, Takagi E, Miyao K, et al. A Tet-on inducible system for controlling CD19-chimeric antigen receptor expression upon drug administration. Cancer Immunol Res. 2016;4:658–68.

  • 32.

    Roellecke K, Virts EL, Einholz R, Edson KZ, Altvater B, Rossig C, et al. Optimized human CYP4B1 in combination with the alkylator prodrug 4-ipomeanol serves as a novel suicide gene system for adoptive T-cell therapies. Gene Ther. 2016;23:615–26.

  • 33.

    Fedorov VD, Themeli M, Sadelain M. PD-1- and CTLA-4-based inhibitory chimeric antigen receptors (iCARs) divert off-target immunotherapy responses. Sci Transl Med. 2013;5:215ra172.

  • 34.

    Morsut L, Roybal KT, Xiong X, Gordley RM, Coyle SM, Thomson M, et al. Engineering customized. Cell Sens Response Behav Using Synth Notch Recept Cell. 2016;164:780–91.

  • 35.

    Singh H, Manuri PR, Olivares S, Dara N, Dawson MJ, Huls H, et al. Redirecting specificity of T-cell populations for CD19 using the Sleeping Beauty system. Cancer Res. 2008;68:2961–71.

  • 36.

    Singh H, Figliola MJ, Dawson MJ, Huls H, Olivares S, Switzer K, et al. Reprogramming CD19-specific T cells with IL-21 signaling can improve adoptive immunotherapy of B-lineage malignancies. Cancer Res. 2011;71:3516–27.


  • ARCA biopharma Announces Second Quarter 2018 monetary Results and Provides Corporate Update | killexams.com existent questions and Pass4sure dumps

    August 09, 2018 16:15 ET | Source: ARCA biopharma, Inc.

    photo-release

    Dr. Bristow - Photo

    Dr. Michael Bristow, President and CEO, ARCA biopharma, Inc.

    ARCA biopharma, Inc.

    WESTMINSTER, Colo., Aug. 09, 2018 (GLOBE NEWSWIRE) -- ARCA biopharma, Inc. (Nasdaq:ABIO), a biopharmaceutical company applying a precision medicine approach to developing genetically-targeted therapies for cardiovascular diseases, today reported monetary results for the quarter ended June 30, 2018.

    “The second quarter of this year saw an famous milestone for the Gencaro evolution program with the completion of an End-of-Phase 2 FDA meeting that provided famous guidance for the next steps in their evolution of Gencaro as potentially the first genetically-targeted treatment for atrial fibrillation,” commented Dr. Michael Bristow, ARCA’s President and Chief Executive Officer.  “With labor underway on completing the Gencaro aspect 3 crucible protocol and continued progress with IND enabling activities for AB171 in PAD and HF, they believe ARCA is advancing their pipeline of genetically-targeted therapeutics to address the unmet medical needs of patients with cardiovascular disease.”

    Pipeline Update

    Gencaro (bucindolol hydrochloride) - a pharmacologically unique beta-blocker and mild vasodilator being developed for the potential treatment of patients with atrial fibrillation (AF) and inveterate heart failure with reduced left ventricular ejection fraction (HFrEF).

  • In April 2018, Medtronic, Inc. and ARCA agreed to extend their current U.S., Canadian and European Clinical crucible Collaboration Agreement for one additional year.
  • In May 2018, results from ARCA’s GENETIC-AF aspect 2B clinical crucible were presented in a “Late Breaking Clinical Trials” oral presentation at the European Society of Cardiology (ESC) Heart Failure 2018 World Congress.
  • In June 2018, ARCA held an End-of-Phase 2 meeting with the U.S. Food and Drug Administration (FDA) to review the GENETIC-AF data and potential future Gencaro evolution plans.
  • FDA concurrence to proceed into aspect 3 was reached. ARCA anticipates submitting a Special Protocol Assessment (SPA) application for the proposed Gencaro aspect 3 clinical crucible in the third quarter of 2018. Progress to aspect 3 is dependent on the Company receiving additional funding.
  • AB171 – a thiol-substituted isosorbide mononitrate being developed as a potential genetically-targeted treatment for heart failure (HF) and peripheral arterial disease (PAD).

  • Chemistry, manufacturing and controls (CMC) activities were continued in the second quarter.
  • IND-enabling non-clinical studies are anticipated to commence in the first half of 2019.
  • Second Quarter 2018 Summary monetary Results

    Cash, cash equivalents and marketable securities totaled $9.6 million as of June 30, 2018, compared to $11.8 million as of December 31, 2017. ARCA believes that its current cash, cash equivalents and marketable securities will exist sufficient to fund its operations, at its projected cost structure, through the discontinue of the first quarter of 2019.

    Research and evolution (R&D) expenses for the quarter ended June 30, 2018 totaled $1.2 million compared to $4.5 million for the corresponding term of 2017.  The $3.3 million dwindle in research and evolution expenses in the second quarter of 2018 as compared to the second quarter 2017 was primarily due to decreased clinical expenses following the completion of the GENETIC-AF clinical trial.  The Company expects R&D expenses in 2018 to exist lower than 2017 as the GENETIC-AF clinical crucible has been completed.

    General and administrative (G&A) expenses for the quarter ended June 30, 2018 were $1.0 million, relatively unchanged compared to the $1.1 million in the second quarter of 2017.  ARCA expects G&A expenses in 2018 to exist consistent with those in 2017 as it maintains administrative activities to champion ongoing operations.

    Total operating expenses for the quarter ended June 30, 2018 were $2.2 million compared to $5.6 million for the second quarter of 2017.  The dwindle in total operating expenses for the second quarter of 2018 was primarily due to the dwindle in R&D expense due to the completion of the GENETIC-AF clinical trial.

    Net loss was $2.1 million, or $0.15 per share, for the second quarter of 2018 compared to $5.5 million, or $0.59 per share, for the second quarter of 2017.

    About ARCA biopharma

    ARCA biopharma is dedicated to developing genetically-targeted therapies for cardiovascular diseases through a precision medicine approach to drug development. ARCA’s lead product candidate, GencaroTM (bucindolol hydrochloride), is an investigational, pharmacologically unique beta-blocker and mild vasodilator being developed for the potential treatment of patients with atrial fibrillation (AF) and inveterate heart failure with reduced left ventricular ejection fraction (HFrEF) which recently completed a aspect 2B clinical trial. ARCA has identified common genetic variations that it believes prognosticate individual patient response to Gencaro, giving it the potential to exist the first genetically-targeted AF prevention treatment. ARCA has a collaboration with Medtronic, Inc. for champion of the GENETIC-AF trial. The Gencaro evolution program has been granted rapid Track designation by FDA. ARCA is too developing AB171, a thiol-substituted isosorbide mononitrate, as a potential genetically-targeted treatment for peripheral arterial disease (PAD) and for heart failure (HF). For more information, please visit www.arcabio.com.

    Safe Harbor Statement

    This press release contains "forward-looking statements" for purposes of the safe harbor provided by the Private Securities Litigation Reform Act of 1995. These statements include, but are not limited to, statements regarding the faculty of ARCA’s monetary resources to champion its operations through the discontinue of the first quarter of 2019, potential future evolution plans for Gencaro, the expected features and characteristics of Gencaro or AB171, including the potential for genetic variations to prognosticate individual patient response to Gencaro, Gencaro’s potential to treat AF, AB171’s potential to treat HF, future treatment options for patients with AF, and the potential for Gencaro to exist the first genetically-targeted AF prevention treatment. Such statements are based on management's current expectations and involve risks and uncertainties.  Actual results and performance could disagree materially from those projected in the forward-looking statements as a result of many factors, including, without limitation, the risks and uncertainties associated with: ARCA’s monetary resources and whether they will exist sufficient to meet its traffic objectives and operational requirements; ARCA may not exist able to raise sufficient capital on acceptable terms, or at all, to continue evolution of Gencaro or to otherwise continue operations in the future; results of earlier clinical trials may not exist confirmed in future trials; the protection and market exclusivity provided by ARCA’s intellectual property; risks related to the drug discovery and the regulatory approval process; and, the impact of competitive products and technological changes.  These and other factors are identified and described in more detail in ARCA’s filings with the Securities and Exchange Commission, including without limitation ARCA’s annual report on profile 10-K for the year ended December 31, 2017, and subsequent filings. ARCA disclaims any intent or duty to update these forward-looking statements.

    Investor & Media Contact:Derek Cole720.940.2163derek.cole@arcabio.com

    (Tables follow)

      ARCA BIOPHARMA, INC.   BALANCE SHEET DATA  (in thousands)  (unaudited)     June 30, 2018   December 31, 2017 Cash, cash equivalents & marketable securities $9,635   $11,752 Working capital $8,950   $10,229 Total assets $10,067   $12,365 Total stockholders’ equity $8,998   $10,275        

     

        ARCA BIOPHARMA, INC.       STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS   (unaudited)         Three Months Ended     Six Months Ended     June 30,     June 30,     2018     2017     2018     2017                                     (in thousands, except participate and per participate amounts)   Costs and expenses:                               Research and development $ 1,154     $ 4,508     $ 2,874     $ 7,754   General and administrative   1,002       1,051       2,055       2,186   Total costs and expenses   2,156       5,559       4,929       9,940   Loss from operations   (2,156 )     (5,559 )     (4,929 )     (9,940 )                                 Interest and other income   43       39       84       84   Interest expense   (3 )     (2 )     (6 )     (4 ) Net loss $ (2,116 )   $ (5,522 )   $ (4,851 )   $ (9,860 )                                 Change in unrealized loss on marketable securities   —       4       2       14   Comprehensive loss $ (2,116 )   $ (5,518 )   $ (4,849 )   $ (9,846 )                                 Net loss per share:                               Basic and diluted $ (0.15 )   $ (0.59 )   $ (0.35 )   $ (1.07 ) Weighted medium shares outstanding:                               Basic and diluted   13,923,512       9,324,822       13,772,947       9,210,186                                  

    A photo accompanying this announcement is available at http://www.globenewswire.com/NewsRoom/AttachmentNg/af496e97-20da-420a-bf93-e51b3a3ed740



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